D. Schoepp. There is a medical need for novel antipsychotic drugs. Currently available drugs modulate dopamine receptors and do not affect cognitive domain of the disease. There also problems with compliance and tolerability of drugs. Schoepp advocates the use of glutamate receptor modulators in the therapy of schizophrenia.

The use of stimulants (methylphenidate and amphetamine) as cognitive enhancers by the general public is increasing and is controversial. It is still unclear how they work or why they improve performance in some individuals but impair it in others. To test the hypothesis that stimulants enhance signal to noise ratio of neuronal activity and thereby reduce cerebral activity by increasing efficiency, we measured the effects of methylphenidate on brain glucose utilization in healthy adults. We...