In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high...

Soshana Wodak, Ph.D. Scientific Director, Centre for Computational Biology (CCB), The Hospital for Sick Children Professor, Biochemistry and Medical Genetics, University of Toronto Canada Research Chair, Computational Biology and Bioinformatics

See these two technologies go head to head in a side-by-side time elapsed protocol

Background The ability to predict antibody binding sites (aka antigenic determinants or B-cell epitopes) for a given protein is a precursor to new vaccine design and diagnostics. Among the various methods of B-cell epitope identification X-ray crystallography is one of the most reliable methods. Using these experimental data computational methods exist for B-cell epitope prediction. As the number of structures of antibody-protein complexes grows, further interest in prediction...

Magnetic separation technology was pioneered by Dynal for the separation of biomagnetic material. Dynabeads technology supports genomics, transcriptomics, proteomics, diagnostics, basic research, clinical cell